2-Methylpyridine-3-boronic acid pinacol ester

2-Methylpyridine-3-boronic acid pinacol ester - Names and Identifiers

Name	2-Methylpyridine-3-boronic acid pinacol ester
Synonyms	2-Methylpyridine-3-boronic acid pinacol ester 2-METHYLPYRIDINE-3-BORONIC ACID PINACOL ESTER 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Pyridine, 2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(2-Methylpyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS	1012084-56-8
InChI	InChI=1S/C12H18BNO2/c1-9-10(7-6-8-14-9)13-15-11(2,3)12(4,5)16-13/h6-8H,1-5H3

2-Methylpyridine-3-boronic acid pinacol ester - Physico-chemical Properties

Molecular Formula	C12H18BNO2
Molar Mass	219.09
Density	1.02±0.1 g/cm3(Predicted)
Boling Point	311.6±30.0 °C(Predicted)
pKa	5.94±0.12(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

2-Methylpyridine-3-boronic acid pinacol ester - Risk and Safety

Hazard Symbols

Xi - Irritant

2-Methylpyridine-3-boronic acid pinacol ester - Introduction

2-Methylpyridine-3-boronic acid pinacol ester is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
2-Methylpyridine-3-boronic acid pinacol ester is a colorless to slightly yellow liquid. It has good solubility and can be dissolved in many organic solvents such as methanol, ethanol and ester solvents.

Use:
2-methylpyridine-3-boronic acid pinacol ester is widely used in chemical synthesis. It can be used as a reagent and catalyst in organic synthesis, can catalyze the oxoalkylation reaction of phenol, and can also catalyze the alkylation and oxoalkylation reaction of alcohol. In addition, it can also be used in the preparation of supported catalysts, such as precursors for supported metal catalysts.

Preparation Method:
The preparation of 2-methylpyridine-3-boronic acid pinacol ester is usually achieved by the reaction of 2-methylpyridine and pinacol ester. In the reaction, boric acid or a salt thereof is used as a catalyst so that the reaction can proceed smoothly. The preparation method is simple and the yield is high.

Safety Information:
2-methylpyridine-3-boronic acid pinacol ester is stable at room temperature, but care should be taken to avoid contact with oxidizing agents. During the operation, care should be taken to avoid inhalation of its vapor and contact with skin and eyes. In case of accidental contact, please rinse with plenty of water in time.

Last Update：2024-04-09 20:52:54